‘The higher the number of vaccines previously received, the higher the risk of contracting COVID-19’ Effectiveness of the Influenza Vaccine During the 2024-2025 Respiratory Viral Season https://www.medrxiv.org/content/10.11… Study to evaluate effectiveness of influenza vaccine during the 2024-2025 respiratory viral season. Methods Employees of Cleveland Clinic in employment in Ohio on October 1, 2024, were included. The cumulative incidence of influenza, Vaccinated status Unvaccinated status Compared over the following 25 weeks. Results Among 53,402 employees, 43,857 (82.1%) had received the influenza vaccine by the end of the study. Influenza occurred in 1,079 (2.02%) during the study. The cumulative incidence of influenza was similar for the vaccinated and unvaccinated states early, but over the course of the study the cumulative incidence of influenza increased more rapidly among the vaccinated than the unvaccinated. In an analysis adjusted for age, sex, clinical nursing job, and employment location, the risk of influenza was significantly higher for the vaccinated compared to the unvaccinated state, HR, 1.27 95% C.I., 1.07 – 1.51 P = 0.007 Yielding a calculated vaccine effectiveness of −26.9% 95% C.I., −55.0 to −6.6% The results are generalizable to relatively healthy adults in the USA, which is a major target of adult influenza vaccination efforts. Although the study was done in northern Ohio, there is little reason to assume that the effectiveness of the vaccine would have been different in a different geographic region within the continental USA. Conclusions This study found that influenza vaccination of working-aged adults was associated with a higher risk of influenza during the 2024-2025 respiratory viral season, suggesting that the vaccine has not been effective in preventing influenza this season. Some details Influenza, respiratory viral infection, 145 000 deaths worldwide among all ages in 2017 1918, case fatality rate 2.5%, more than 50 million deaths worldwide Seasonal pattern to illness Annual influenza vaccination is often recommended Trivalent inactivated vaccine (TIV), two influenza A virus types (H3N2 and H1N1), and an influenza B virus type Efficacy will vary depending on prognostication mRNA pressure?
Flu vac causing flu
‘The higher the number of vaccines previously received, the higher the risk of contracting COVID-19’ Effectiveness of the Influenza Vaccine During the 2024-2025 Respiratory Viral Season https://www.medrxiv.org/content/10.11… Study to evaluate effectiveness of influenza vaccine during the 2024-2025 respiratory viral season. Methods Employees of Cleveland Clinic in employment in Ohio on October 1, 2024, were included. The cumulative incidence of influenza, Vaccinated status Unvaccinated status Compared over the following 25 weeks. Results Among 53,402 employees, 43,857 (82.1%) had received the influenza vaccine by the end of the study. Influenza occurred in 1,079 (2.02%) during the study. The cumulative incidence of influenza was similar for the vaccinated and unvaccinated states early, but over the course of the study the cumulative incidence of influenza increased more rapidly among the vaccinated than the unvaccinated. In an analysis adjusted for age, sex, clinical nursing job, and employment location, the risk of influenza was significantly higher for the vaccinated compared to the unvaccinated state, HR, 1.27 95% C.I., 1.07 – 1.51 P = 0.007 Yielding a calculated vaccine effectiveness of −26.9% 95% C.I., −55.0 to −6.6% The results are generalizable to relatively healthy adults in the USA, which is a major target of adult influenza vaccination efforts. Although the study was done in northern Ohio, there is little reason to assume that the effectiveness of the vaccine would have been different in a different geographic region within the continental USA. Conclusions This study found that influenza vaccination of working-aged adults was associated with a higher risk of influenza during the 2024-2025 respiratory viral season, suggesting that the vaccine has not been effective in preventing influenza this season. Some details Influenza, respiratory viral infection, 145 000 deaths worldwide among all ages in 2017 1918, case fatality rate 2.5%, more than 50 million deaths worldwide Seasonal pattern to illness Annual influenza vaccination is often recommended Trivalent inactivated vaccine (TIV), two influenza A virus types (H3N2 and H1N1), and an influenza B virus type Efficacy will vary depending on prognostication mRNA pressure?